Interest in plant-derived alternative medicine that affects the “Brain” is attenuating due to the deleterious effects of modern era synthetic drugs. The aim of present study was to explore the anti-anxiety activity of ethanolic and aqueous extracts of fruits of Ziziphus jujuba herb using elevated plus maze anti-anxiety model in mice. Diazepam (2mg/kg) was used as the standard and two each doses of ethanol and aqueous extracts i.e., 200 and 400 mg/kg were selected for study as per OECD guidelines. Results suggested that extract of Z. jujuba at 200 mg/kg dose produced anti-anxiety effects almost similar to diazepam. Further studies are needed to identify the anxiolytic mechanism(s) and the phytoconstituents responsible for the observed central effects of the ethanolic and aqueous extracts of fruits of Z. jujuba.
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